Intestinal dysbiosis in inflammatory bowel disease
نویسندگان
چکیده
منابع مشابه
Dysbiosis in inflammatory bowel disease.
Abundant data have incriminated intestinal bacteria in the initiation and amplification stages of inflammatory bowel diseases. However, the precise role of intestinal bacteria remains elusive. One theory has suggested a breakdown in the balance between putative species of "protective" versus "harmful" intestinal bacteria--this concept has been termed "dysbiosis". Arguments in support of this co...
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Intestinal bacteria have been implicated in the initiation and amplification of inflammatory bowel disease (IBD). The dysbiosis theory, reviewed by Tamboli et al (Gut 2004;53:1), is that an imbalance between putative ‘‘harmful’’ versus ‘‘protective’’ bacterial species may promote chronic intestinal inflammation. Although several studies published so far support this hypothesis, the most vexing ...
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Gut microbiota is a compilation of microorganisms dwelling in the entire mammalian gastrointestinal tract. They display a symbiotic relationship with the host contributing to its intestinal health and disease. Even a slight fluctuation in this equipoise may be deleterious to the host, leading to many pathological conditions like Clostridium difficile infection or inflammatory bowel disease (IBD...
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The intestinal epithelium has a strategic position as a protective physical barrier to luminal microbiota and actively contributes to the mucosal immune system. This barrier is mainly formed by a monolayer of specialized intestinal epithelial cells (IECs) that are crucial in maintaining intestinal homeostasis. Therefore, dysregulation within the epithelial layer can increase intestinal permeabi...
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Crohn's disease (CD) and ulcerative colitis (UC) are the two principal forms of inflammatory bowel disease (IBD). Animal studies show that bacteria are involved in the etiology of IBD, and much is now known about the inflammatory processes associated with CD and UC, as well as the underlying genetic, environmental, and lifestyle issues that can affect an individual's predisposition to these dis...
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ژورنال
عنوان ژورنال: Gut Microbes
سال: 2011
ISSN: 1949-0976,1949-0984
DOI: 10.4161/gmic.2.4.17863